February 25, 2022
A team of Taiwanese researchers availed themselves of the country's National Health Insurance Research Database (NHIRD) to explore the links between exposure to general anesthesia and ADHD. Taiwan has a single-payer health insurance system that encompasses 99% of its more than 23 million residents. NHIRD is a database of one million persons randomly selected from those insurance records.
The study sample consisted of 43,377 children under three years old who were admitted to hospitals between 1997 and 2008, with or without exposure to general anesthesia.
Next, individuals from both groups were matched by age, gender, and admission to the hospital within a week of each other. Two controls not exposed to general anesthesia were matched to every case that was exposed. The resulting cohort of cases with exposure to general anesthesia totaled 2,261 matched to 4,522 controls without such exposure.
Of the inpatients exposed to anesthesia, 67 (2.96%) were subsequently diagnosed with ADHD, whereas among those not exposed, 139 (3.07%) were subsequently found to have ADHD. After adjusting for allergic diseases and age, those exposed to anesthesia were 6% less likely to be diagnosed with ADHD, but the result lacked any statistical significance.
The authors concluded, "There was no significant difference in the overall incidence of ADHD, autism and intellectual disability between the GA-exposed group and the comparison cohort."
Ya-Ling Yang, Liang-Jen Wang, Jung-Chan Chang, Shu-Chen Ho, and Ho-Chang Kuo, "A National Population Cohort Study Showed That Exposure to general Anesthesia in Early Childhood Is Associated with an Increase in the Risk of Developmental Delay," Children(2021), 8, 840, published online,https://doi.org/10.3390/children8100840.